Key Allergy Gene Discovered
ScienceDaily (Aug. 25, 2008) — Together with colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment (ZAUM) of the Technische Universität München, scientists at the Helmholtz Zentrum München have pinpointed a major gene for allergic diseases.
The gene was localized using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum München.
The newly discovered FCER1A gene encodes the alpha chain of high affinity IgE receptor, which plays a major role in controlling allergic responses. The team of scientists led by Dr. Stephan Weidinger from the Technische Universität München and Dr. Thomas Illig from the Helmholtz Zentrum München found that certain variations of the FCER1A gene decisively influence the production of immunoglobulin E (IgE) antibodies. IgE antibodies are a particular type of antibody that is normally used to protect against parasites. In Western lifestyle countries with less contact, however, elevated IgE levels are associated with allergic disorders.
In genetically susceptible individuals the immune system becomes biased and produces IgE antibodies against harmless agents such as pollen, dust mites or animal hair. These IgE antibodies then work in conjunction with certain cells to get rid of the allergens, a process that gives rise to the symptoms of allergy such as allergic rhinitis (hay fever), atopic dermatitis or asthma.
